Clinical Significance of Fascin Expression in Elderly Patients Over 65 Years Old with a Newly Diagnosed Primary Glioblastoma

, Won Young Kim1; , Jeong-Taik Kwon1; , Taek Kyun Nam1; , Ki-Su Park1; , Jeong Hyun Hwang2; , Kyoung-Tae Kim2

Clinical Article

Journal of Korean Society of Geriatric Neurosurgery 2016;12(2):179-184.
Published online September 30, 2016.

Clinical Significance of Fascin Expression in Elderly Patients Over 65 Years Old with a Newly Diagnosed Primary Glioblastoma

Won Young Kim1 , Jeong-Taik Kwon1 , Taek Kyun Nam1 , Ki-Su Park1 , Jeong Hyun Hwang2 , Kyoung-Tae Kim2

¹Department of Neurosurgery, Chung-Ang University College of Medicine, Seoul, ²Department of Neurosurgery, Kyungpook National University School of Medicine, Daegu, Korea

65세 이상 노인 환자의 새로 진단된 원발성 교모세포종에서 Fascin 발현의 임상적 중요성

김원영¹·권정택¹·남택균¹·박기수¹·황정현¹·김경태²

중앙대학교 의과대학 신경외과학교실¹, 경북대학교 의과대학 신경외과학교실²

Abstract

Objective
The actin-binding protein fascin has been associated with clinically aggressive tumors and poor prognosis. The purpose of this study was to investigate possibility of fascin expression as a prognostic factor in elderly patients over 65 years old with a newly diagnosed primary glioblastoma (GBM).
Methods
Between July 2007 and December 2013, 13 out of 126 patients diagnosed with GBM satisfied the following inclusion criteria: (1) elderly patients over 65 years old, (2) the presence of immunohistochemically-available tissue, (3) a new primary GBM, (4) near-total resection, and (5) standardized adjuvant treatment, known as the Stupp regimen.
Results
The median follow-up period was 18 months (range, 5-95). According to the staining intensity of fascin, progression-free survival (PFS) in the low-intensity fascin group (median PFS, 9.0 months; 95% CI, 6.0-12.0) was longer than PFS in the high-intensity fascin group (median PFS, 7.0 months; 95% CI, 5.6-10.4; p=0.024). Overall survival (OS) in the low-intensity fascin group (median OS, 20.0 months; 95% CI, 17.7-22.4) was longer than OS in the high-intensity fascin group (median OS, 13.0 months; 95% CI, 8.2-17.8; p=0.031). And, the staining intensity of fascin was a statistically significant factor in PFS and OS according to univariate and multivariate analysis (univariate analysis: p=0.043 and p=0.043; multivariate analysis: p=0.041 and p=0.044).
Conclusion
Our clinical study showed that fascin expression intensity may be correlated with clinical outcomes of elderly patients over 65 years old with a newly diagnosed primary GBM, especially with regard to PFS and OS.

Key Words: Elderly, Glioblastoma, Fascin, Overall, Survival, Progression-free survival